TREM and LILR Receptors in Neurodegeneration and Cancer

Marco Colonna, MD, Robert Rock Belliveau Professor, Pathology and Immunology, Washington University School of Medicine in St. Louis

CD40 agonists and impact on myeloid cells in cancer.

Robert Vonderheide, MD, DPhil, Director of the Abramson Cancer Center, John H. Glick Abramson Cancer Center Professor, University of Pennsylvania, USA

A new framework for understanding immunomodulatory myeloid cells in glioma (and other solid tumors)

Tyler Miller, MD, PhD, Research Fellow, Department of Pathology Massachusetts General Hospital and Department of Cancer Biology Dana Farber Cancer Institute, USA

Targeting Myeloid cells in Immuno-oncology

The Myeloid Network is proud to partner with the Society for Immunotherapy of Cancer (SITC) to co-host the 2023 Pre-Conference Program at the SITC 38th Annual Meeting in San Diego, CA, USA.

Member registration & early housing access opens Wednesday, April 26.

In-Person and virtual format available. 

https://www.sitcancer.org/2023/home

Targeting mononuclear phagocytes for tumor immunotherapy 

Malay Haldar, MD, PhD, Associate Professor, Department of Pathology and Laboratory Medicine, Assistant Investigator, Abramson Family Cancer Research Institute, Abramson Cancer Center, Sarcoma Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA

Second year anniversary symposium

11:00AM - 3:40PM EST / 8:00AM - 12:40PM PST

KEYNOTE SPEAKERS:
Simon T Barry, MD, AstraZeneca
Jashodeep Datta, MD FSSO FACS, Miller School of Medicine, University of Miami

SCHEDULE

11:00 AM EST / 8:00 AM PST – Welcome and Introduction                         

11:10 AM EST / 8:10 AM PST – KEYNOTE
Simon Barry, PhD, Senior Principal Scientist, AstraZeneca, USA  

Opportunities and challenges for myeloid cell targeting drugs in cancer

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11:40 AM EST / 8:40 AM PST – Rongze "Olivia" Lu, PhD, Principal Investigator, Brain Tumor Center; Assistant Professor, Department of Neurological Surgery, University of California, San Francisco, USA

PP2Ac/STRN4 negatively regulates STING-Type I interferon signaling in tumor associated macrophages

11:55 AM EST / 8:55 AM PST – María M. Caffarel, PhD, Ikerbasque Research Associate, Biodonostia Health Research Institute, San Sebastian, Spain.

Modulation of tumour-promoting inflammation in breast cancer by Oncostatin M cytokine: implications in immune suppression

12:10 PM EST / 9:10 AM PST – Helen S. Goodridge, PhD, Professor, Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA    

Impact of aging and sex differences on the transcriptomes and metabolic programming of hippocampal microglia.

12:25 PM EST / 9:25 AM PST – Helen McRae, PhD, Postdoctoral Fellow, Hargreaves Lab, Salk Institute for Biological Studies, La Jolla, CA, USA          

Epigenetic Reprogramming of Tumor-Associated Macrophages: targeting the BAF nucleosome remodeling complex to boost response to anti-PD-L1 immunotherapy

12:40 PM EST / 9:40 AM PST – Michelle M Williams, PhD, Postdoctoral Fellow Department of Pathology, Richer Lab University of Colorado Anschutz Medical Campus, USA          

Breast tumor cell heme metabolism alters macrophage immune suppression and function to support lung metastasis

-------------------- 12:55 PM EST / 9:55 AM  PST – BREAK --------------------             

1:15 PM EST / 10:15 AM PST – KEYNOTE
Jashodeep Datta, MD FSSO FACS, DiMare Family Chair in Cancer Immunotherapy, Assistant Professor of Surgery, University of Miami Miller School of Medicine; Associate Director, Translational Research, Sylvester Pancreatic Cancer Institute Sylvester Comprehensive Cancer Center, Miami, FL, USA

Deconstructing Cancer Cell-Neutrophil Circuitry that Sustains Immunosuppressive Networks in Pancreatic Cancer 

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1:45 PM EST / 10:45 AM PST – Asaf Maoz, MD, Oncology fellow at Dana-Farber Cancer Institute (DFCI) and Massachusetts General Hospital (MGH), Postdoctoral Fellow, Whitehead Institute for Biomedical Research, Cambridge, MA, USA      

Unbiased phenotypic screens identify IL-10 as an enhancer of macrophage anti-tumor responses to CD47 blockade and tumor-opsonizing antibodies

2:00 PM EST / 11:00 AM PST – Brenda O'Connell, PhD, Director, Translational Science, Infinity Pharmaceuticals

Eganelisib, a Potential First-in-Class PI3K-𝛾 Inhibitor for Next Generation Macrophage Reprogramming Cancer Immunotherapy

2:15 PM EST / 11:15 AM PST – Charlene Liao, PhD, President and CEO of Immune-Onc Therapeutics, Inc.        

Novel Myeloid Checkpoint Inhibitors as Next Generation Cancer Immunotherapy

-------------------- 2:30 PM EST / 11:30 AM  PST – BREAK --------------------                   

2:50 PM EST / 11:50 AM PST – Hannah Garner, PhD, Postdoctoral Fellow, Karin de Visser Group, Division of Tumor Biology and Immunology, Netherlands Cancer Institute  

Understanding how breast tumours hijack myelopoiesis to promote immunosuppression and disease progression

3:05 PM EST / 12:05 PM PST – William Hill, PhD, Postdoctoral Fellow, Swanton Lab, Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK          

Lung Adenocarcinoma Promotion by Air Pollutants

3:20 PM EST / 12:20 PM PST – Sofia de Oliveira, PhD, Assistant Professor, Department of Developmental & Molecular Biology, Albert Einstein College of Medicine      

Metainflammation impacts neutrophil biology- lessons from the zebrafish

3:35 PM EST / 12:35PM PST – Closing 

Eosinophil - adaptive immune cell crosstalk regulates response to immune checkpoint blockade in breast cancer

Karin de Visser, PhD, Group Leader, Division of Tumor Biology & Immunology at the Netherlands Cancer Institute, Amsterdam, Netherlands

A spatial map of human macrophage niches reveals context dependent macrophage functions

Matt van de Rijn, MD, Professor of Pathology, Department of Pathology, Stanford University, Stanford, California, USA

Magdalena Matusiak, PhD, Department of Pathology, Stanford University, Stanford, California, USA

The dark web of cancer: How neutrophil extracellular traps orchestrate metastasis

Mikala Egeblad, PhD, Professor, Cold Spring Harbor Laboratory, co-leader of the Cold Spring Harbor Laboratory Cancer Center Program on Cellular Communication in Cold Spring Harbor, NY, USA

Diverse Roles of Myeloid Subsets in Fibrosis and Tumor Immunity

David G. DeNardo, PhD, Professor Department of Medicine, Oncology Division, Molecular Oncology, Department of Pathology & Immunology, Washington University School of Medicine in St. Louis, USA

Myeloid biology: what connects cancer and stroke

Li Yang, Ph.D, Senior Investigator, Head, Tumor Microenvironment and Metastasis, Laboratory of Cancer Biology and Genetics, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, MD, USA

Arming tumor-associated macrophages to target cancer stem cells

Hiromi Wettersten, DVM/PhD, Assistant Professor, University of California Sand Diego School of Medicine, La Jolla, CA, USA

Myeloid cells in cancer: a tale of destiny or nurture 

Dmitry Gabrilovich, MD, PhD, Chief Scientist, Cancer Immunology at AstraZeneca in Gaithersburg, MD, USA

Macrophage Syk drives immunosuppression in the tumor microenvironment

Shweta Joshi, PhD, Assistant Professor, Department of Pediatrics, Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA

Unlocking the potential of macrophages in human cancer: Overcoming the IL-10 checkpoint in liver metastasis

Teresa Kim, MD, Assistant Professor, University of Washington Medical Center, Seattle, WA, USA

One year anniversary symposium

9:00-3:00 EST

FULL SCHEDULE HERE.

Keynote speakers:
Ido Amit - Weizmann Institute of Science (Video below)
Miriam Merad - Icahn School of Medicine at Mount Sinai

Invited Speakers:
Florent Ginhoux - Agency for Science, Technology and Research (A*STAR), Singapore
Megan Ruhland - Oregon Health & Science University

Short Talks:
William Zhang - Weill Cornell Medicine
Kim Reiss - University of Pennsylvania 
Diletta DiMitri - IRCCS Istituto Clinico Humanitas Cancer Center
Ryan Shepard - University of California San Diego
Kelly Kersten -  University of California San Francisco
Thomas Ashhurst - University of Sydney
Andreas Mueller - Otto-von-Guericke-University Magdeburg

Round Table Discussion: Defining suppressive myeloid cells and MDSCs
Dmitry Gabrilovich  - AstraZeneca
Miriam Merad - Icahn School of Medicine at Mount Sinai

Round Table Discussion: TRM vs BMDM
Judy Varner -  University of California San Diego
Maria Casanovas-Acebes -  Centro Nacional de Investigaciones Oncológicas
David DeNardo - Washington University School of Medicine

Career Mentoring Session: Career Trajectories
Dmitry Gabrilovich - AstraZeneca
Johanna Joyce - University of Lausanne and the Ludwig Institute for Cancer Research
Michael Klichinsky - Carisma Therapeutics

Career Mentoring Session: Starting your lab and managing your lab
Lisa Coussens - Oregon Health & Science University
Leila Akkari - Netherlands Cancer Institute

Targeting intra-tumoral dendritic cells 

Brian Ruffell, PhD, Moffitt Cancer Center, Department of Immunology & Department of Breast Oncology, Tampa, FL, USA

Question and Answers from the seminar can be found here: Q&A Dr. Ruffell.

Myeloid cells in the pleural cavity: insights from a tissue-dwelling nematode 

Judith Allen, PhD, Lydia Becker Institute of Immunology & Inflammation, University of Manchester, Manchester, United Kingdom

The myelopoiesis in cancer and Covid-19 patients

Vincenzo Bronte, MD, Department of Medicine, University of Verona, Verona, Italy

Exploring and exploiting the functions of myeloid cells in cancer

Johanna Joyce, PhD, Department of Oncology, UNIL/ CHUV, and Lausanne branch of the Ludwig Institute for Cancer Research within the Swiss Cancer Center Léman (SCCL)

Targeting tumor associated macrophages in advanced breast cancer 

Jennifer Guerriero, PhD, Department of Surgery, Division of Breast Surgery, Brigham and Women's Hospital, Boston, USA 

Macrophages in tumor metastasis and immunotherapy resistance

Weiping Zou, MD, PhD, Departments of Surgery and Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA

Microenvironmental resistance to PDL1-PD1 blockade in lung cancer: Role of myeloid cells

Miki De Palma , PhD, Swiss Federal Institute of Technology of Lausanne (EPFL), Switzerland

Non-canonical neutrophils 

Andrés Hidalgo, PhD, Spanish National Centre for Cardiovascular Research, Madrid, Spain

Question and Answers from the seminar can be found here: Q&A Dr. Hidalgo.